Reactions of Rabbits to Intracutaneous Injections of Pneumococci and Their Products

REACTIONS OF RABBITS TO INTRACUTANEOUS INJEC- TIONS OF PNEUMOCOCCI AND THEIR PRODUCTS IV. THE DEVELOPMENT OF SKIN REACTIVITY TO DERIVATIVES OF PNELr~OCOCCUS BY LOUIS A. JULIANELLE, PH.D

Reactions in Skin and in Internal Organs of Rabbits Sensitized with Streptococcus or with Pneumococcus Vaccine and Their Relationship to Antibodies

1. Homologous vaccine was injected into abdominal organs of rabbits after different intervals following sensitization by a single or by repeated intracutaneous injections of heat-killed pneumococci Type I or of formalin-killed hemolytic streptococci (Strain AB(13)). 2. Local inflammation with or without necrosis was observed in the liver and in the spleen of most of the rabbits. Injections into...

Reactions of Rabbits to Intracutaneous Injec- Tions of Pneumococci and Their Products v. the Development of Eye Reactivity to Derivatives of Pneumococci by Louis A. Julianelle, Ph.d

Methods.--The injection of rabbits with Pneumococcus or its derivatives was carried out as described in a previous communication (1). Eye Test.--Eye tests were done according to the technique described by Derick and Swift (3, 4). The cornea was anesthetized with one drop of 10 per cent novocaine, and then it was lightly scarified with a cataract knife. Three scratches were made on one of the up...

Relation of Hypersensitiveness to Lesions in the Lungs of Rabbits Infected with Pneumococci

Certain writers have drawn attention to the effect of active immunization or sensitization (1-6) on the occurrence or character of lesions in the lungs of animals artificially infected with pneumococci. On the basis of these observations some investigators have attempted to explain the pathogenesis of pneumonia in man. In a recent paper, Stuppy, Cannon, and Falk (7) report that after daily insu...

A Comparison of Cutaneous Sensitization and Antibody Formation in Rabbits Immunized by Intravenous or Intradermal Injections of Indifferent or Hemolytic Streptococci and Pneumococci

1. Rabbits that had received repeated intravenous injections of heat-killed indifferent streptococci with no resulting sensitization were subsequently made skin-sensitive to them by repeated intracutaneous injection of heat-killed vaccine. 2. Serum agglutinins and precipitins developed earlier in rabbits that had received repeated intravenous injections of killed streptococci and pneumococci th...